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How your CYP enzymes may affect common medications

Medication Response Education

These genes are part of how your body handles many common medications. This is educational only — real prescribing needs a clinical-grade test.

CYP2C9 · rs1799853

*2

Could be a problem
Your genotypeC / TOne variant copy
Chromosomechr 10Reference C · Variant T
Evidence
Level A
Reviewed 2025-01
In plain language
CYP2C9 processes many medications including NSAIDs (ibuprofen), warfarin, and some diabetes drugs.
What this may suggest
The T version processes some medications more slowly. CPIC has real prescribing guidance for warfarin.
What this does NOT tell us
Consumer files are not clinical-grade. A pharmacist or doctor should confirm before changing any medication.
Simple food & lifestyle ideas
  • Keep an up-to-date medication list to share at every visit.

Questions for your clinician

  • “Given this variant, do any of my current medications need a second look?”
CYP2C19 · rs4244285

*2

Could be a problem
Your genotypeG / AOne variant copy
Chromosomechr 10Reference G · Variant A
Evidence
Level A
Reviewed 2025-01
In plain language
CYP2C19 processes acid-reflux drugs (like omeprazole), some antidepressants, and clopidogrel (a blood thinner).
What this may suggest
The A version reduces enzyme activity. This is one of the best-studied pharmacogenes.
What this does NOT tell us
Consumer data is not enough for prescribing. A clinical PGx test is the standard.
Simple food & lifestyle ideas
  • Keep this note in your health record.

Questions for your clinician

  • “If I ever need clopidogrel or an SSRI, is CYP2C19 testing worth doing clinically?”
CYP2D6 · rs3892097

*4

Low-priority conversation
Your genotypeC / CTypical (no variant copies)
Chromosomechr 22Reference C · Variant T
Evidence
Level A
Reviewed 2025-01
In plain language
CYP2D6 processes about 1 in 4 prescription medications, including codeine, tramadol, tamoxifen, and many antidepressants.
What this may suggest
*4 is a non-functional version. Consumer files only see one piece of the CYP2D6 puzzle — the full picture needs a clinical test.
What this does NOT tell us
This does NOT give you a full CYP2D6 status. Do not use consumer results to change medications.
Simple food & lifestyle ideas
  • Ask your pharmacist to flag CYP2D6 drugs in your record.

Questions for your clinician

  • “If I ever need pain medicine or an antidepressant, would a clinical CYP2D6 test help?”
CYP3A5 · rs776746

*3

High-priority conversation
Your genotypeC / CTwo variant copies
Chromosomechr 7Reference T · Variant C
Evidence
Level A
Reviewed 2025-01
In plain language
CYP3A5 processes tacrolimus (transplant medicine) and some others.
What this may suggest
Most people of European ancestry carry the CC form, which means low activity. That is common and not a problem in itself.
What this does NOT tell us
This is not a prescribing test.
Simple food & lifestyle ideas
  • Note in your medical record if relevant.

What this chapter does NOT tell you

Your genes are one signal. Blood work, symptoms, family history, medications, and your daily life all matter more than any single result on this page. Bring these notes to a clinician who knows you — do not start, stop, or change medications or high-dose supplements based on this report alone.