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Estrogen pathways and processing

Hormone Metabolism

These genes shape how your body breaks down and clears hormones like estrogen.

CYP1B1 · rs1056836

L432V

Could be a problem
Your genotypeC / GOne variant copy
Chromosomechr 2Reference C · Variant G
Evidence
Level C
Reviewed 2025-01
In plain language
CYP1B1 is part of how your body breaks down estrogen. Different versions favor slightly different byproducts.
What this may suggest
May shift the ratio of estrogen metabolites — a topic often discussed in perimenopause.
What this does NOT tell us
Does not diagnose hormone imbalance or predict cancer risk on its own.
Simple food & lifestyle ideas
  • Broccoli, cabbage, and Brussels sprouts contain compounds that support estrogen metabolism.
  • Regular fiber intake helps clear used hormones.

Questions for your clinician

  • “Would a hormone metabolite panel be useful for me?”
  • “Are cruciferous veggies (or DIM) worth including in my routine?”

What this chapter does NOT tell you

Your genes are one signal. Blood work, symptoms, family history, medications, and your daily life all matter more than any single result on this page. Bring these notes to a clinician who knows you — do not start, stop, or change medications or high-dose supplements based on this report alone.